Please use this identifier to cite or link to this item: http://repositorio.uptc.edu.co/handle/001/2366
Title: Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina
Other Titles: Synthesis, antibacterial activity and interaction of DNA with lanthanide-β-cyclodextrin inclusion complexes
Authors: Mayor Rivera, Angélica María
Aragón Muriel, Alberto
Polo Cerón, Dorian
Keywords: Actividad antibacteriana
Complejos de inclusión
Complejos lantánidos
Interacción con ADN
Issue Date: 1-Jul-2018
Publisher: Universidad Pedagógica y Tecnológica de Colombia
Citation: Mayor Rivera, A. M., Aragón Muriel, A. & Polo Cerón, D. (2018). Síntesis, actividad antibacteriana e interacción del ADN con complejos de inclusión entre compuestos lantánidos y β-ciclodextrina. Ciencia en Desarrollo, 9(2), 99-117. DOI: https://doi.org/10.19053/01217488.v9.n2.2018.7365. http://repositorio.uptc.edu.co/handle/001/2366
Abstract: En este trabajo se han sintetizado complejos de lantánidos a partir de los cloruros de La(III), Ce(III), Sm (III) e Yb(III) con ligandos cinamato, presentando coordinación bidentada entre el grupo carboxilo del ligando y el metal lantánido. Estos compuestos se utilizaron como huéspedes de la β-ciclodextrina con el fin de obtener nuevos complejos de inclusión mediante el método de co-precipitación, utilizando N,N-dimetilformamida como disolvente. Los productos de inclusión obtenidos fueron caracterizados mediante espectroscopía IR-ATR, Raman, UV-vis, RMN 1H y 13C, DRX, TGA, DSC, análisis elemental y complexometría con EDTA. Se realizaron pruebas de actividad antibacteriana empleando 6 cepas ATTC (S. aureus ATCC 25923, S. aureus ATCC 29213, E. coli ATCC 25922, P. aeruginosa ATCC 27853, S. Typhimurium ATCC 14028 y K. pneumoniae ATCC BAA-2146) mediante el método de microdilución con caldo Mueller-Hinton; los resultados de actividad biológica para los complejos lantánidos permitieron evidenciar el efecto sinérgico entre el catión lantánido y el ligando cinamato. Igualmente, para los complejos de inclusión se observó una disminución de la concentración mínima inhibitoria (CMI) respecto a los complejos lantánidos iniciales. Los resultados obtenidos con el ADN de timo de ternera y el ADN plasmídico pBR322 permiten proponer una interacción electrostática entre los complejos evaluados y la estructura molécular del ADN.
Description: 1 recurso en línea (páginas 99-117).
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URI: http://repositorio.uptc.edu.co/handle/001/2366
ISSN: 2462-7658
Series/Report no.: Ciencia en Desarrollo;Volumen 9, número 2 (Julio-Diciembre 2018)
Appears in Collections:Ciencia en Desarrollo

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