Obtención de nanofibras Core/Shell de Acido Poliláctico/Carboximetil celulosa para su aplicación en liberación controlada de fármacos

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dc.contributor.advisorMuñoz Prieto, Efren de Jesússpa
dc.contributor.advisorOlayo González, Robertospa
dc.contributor.authorLeón Pérez, Jadileyg Gabriela
dc.date.accessioned2019-03-29T15:52:22Z
dc.date.available2019-03-29T15:52:22Z
dc.date.issued2018
dc.description1 recurso en línea (84 páginas) : figuras, tablas.spa
dc.description.abstractLas nanofibras Core/Shell son un desarrollo revolucionario en el campo de la ciencia y la tecnología. La obtención de estas fibras a nanoescala mediante la técnica de electrohilado coaxial presenta potenciales aplicaciones médicas, entre ellas, la capacidad de incorporar y liberar fármacos de manera controlada. La carga de fármacos en nanofibras utilizando la técnica de electrohilado convencional produce tasas de liberación muy altas al inicio, las cuales disminuyen con el tiempo, al contrario de la configuración core/shell en la que se pueden obtener porcentajes de liberación de la droga más controlados debido la presencia de una envoltura y/o capa que protege el fármaco de la exposición directa con el medio de liberación. Dada la necesidad de reducir las dosis de medicamento ingeridas por un paciente y prolongar su efecto; se plantea un sistema de liberación de fármacos in vitro que permita mantener una liberación sostenida de la droga durante largos periodos. El presente proyecto de investigación se enfocó en la obtención de fibras core/shell por medio de la técnica de electrohilado coaxial, utilizando polímeros biodegradables como Carboximetil Celulosa (CMC) y Ácido Poliláctico (PLA), además, se evaluó el comportamiento de las nanofibras como potenciales vehículos de liberación de Curcumina (Cur), fitoquímico que ha sido objeto de ensayos clínicos debido a su gran actividad biológica, entre las que se destacan sus propiedades antiinflamatorias, antioxidantes, antitumorales y quimiopreventivas. Posteriormente, se caracterizó la estructura química de las nanofibras de CMC/PLA-Cur mediante técnicas instrumentales tales como Microscopia Electrónica de Barrido (SEM), Espectroscopia Infrarroja con Transformada de Fourier (FTIR), Espectroscopia Raman, Análisis Termogravimétrico (TGA) y Calorimetría Diferencial de Barrido (DSC). Se determinaron las tasas de dosificación in vitro de las nanofibras mediante Espectroscopia UV-VIS y los perfiles de liberación de Cur se ajustaron al modelo matemático de Korsmeyer-Peppas, obteniéndose como resultado, un mecanismo basado en la difusión/erosión de la matriz polimérica.spa
dc.description.abstractThe core/shell nanofibers are a revolutionary development in the field of science and technology. The obtaining of these fibers at the nanoscale using the coaxial electrospinning technique presents potential medical applications, among them, the ability to incorporate and release drugs in a controlled manner. The loading of drugs in nanofibers using the conventional electrospinning technique produces very high release rates at the beginning, which decrease enormously over time, in contrast to the core/shell configuration in which percentages of release can be obtained more controlled drugs due to the presence of a shell and/or layer that protects the drug from direct exposure with the release medium. Given the need to reduce the doses of medication ingested by a patient and prolong its effect; an in vitro drug release system is proposed that allows to maintain a sustained release of the drug for long periods. The present research project focused on the obtaining of core/shell fibers by means of the coaxial electrospinning technique, using biodegradable polymers such as Carboxymethyl Cellulose (CMC) and Polylactic Acid (PLA), in addition, the behavior of the nanofibers was evaluated as potential release vehicles of Curcumin (Cur), a phytochemical that has been subject to clinical trials due to its great biological activity, among which its anti-inflammatory, antioxidant, antitumor and chemopreventive properties stand out. Later, the chemical structure of the nanofibers of CMC/PLA-Cur was characterized by instrumental techniques such as Scanning Electron Microscopy (SEM), Infrared Spectroscopy with Fourier Transform (FTIR), Raman Spectroscopy, Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry. (DSC). The in vitro dosage rates of the nanofibers were determined by UV-VIS spectroscopy and the Cur release profiles were adjusted to the Korsmeyer-Peppas mathematical model, obtaining as a result, a mechanism based on the diffusion/erosion of the polymeric matrix.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Químicaspa
dc.description.notesBibliografía y webgrafía: páginas 74-79.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationLeón Pérez, J. G. (2018). Obtención de nanofibras Core/Shell de Acido Poliláctico/Carboximetil celulosa para su aplicación en liberación controlada de fármacos. (Tesis de maestría). Universidad Pedagógica y Tecnológica de Colombia, Tunja. http://repositorio.uptc.edu.co/handle/001/2505spa
dc.identifier.urihttp://repositorio.uptc.edu.co/handle/001/2505
dc.language.isospaspa
dc.publisherUniversidad Pedagógica y Tecnológica de Colombiaspa
dc.publisher.facultyFacultad de Ciencias, Escuela de Posgrados. Maestría en Químicaspa
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dc.relation.referencesDewangan, A.; et al. “Preparation, characterization and anti-inflammatory effects of curcumin loaded carboxymethyl cellulose acetate butyrate nanoparticles on adjuvant induced arthritis in rats”. J Drug Deliv Sci. Vol. 41, pp. 269-279, 2017.spa
dc.relation.referencesTrang, M.; el al. “A novel nanofiber Cur-loaded polylactic acid constructed by electrospinning”. Adv. Nat. Sci.: Nanosci. Nanotechnol. Vol. 3, pp. 4, 2012.spa
dc.relation.referencesYang, J.; et al. “Preparation and Characterization of Electrospinning PLA/Curcumin Composite Membranes”. Fiber Polym. Vol. 11 (8), pp. 1128-1131, 2010.spa
dc.rightsCopyright (c) 2018 Universidad Pedagógica y Tecnológica de Colombiaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.armarcNanofibras
dc.subject.armarcMateriales nanoestructurados
dc.subject.armarcNanohilos
dc.subject.armarcCarboximetil celulosa
dc.subject.armarcNanofibras Core-Shell
dc.subject.armarcMaestría en Química - Tesis y disertaciones académicas
dc.subject.armarcAcido polilácticospa
dc.titleObtención de nanofibras Core/Shell de Acido Poliláctico/Carboximetil celulosa para su aplicación en liberación controlada de fármacosspa
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttps://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
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