Estudio teórico-experimental de la síntesis y propiedades físico-químicas de derivados de N-bencil-1-(2-furanil) Metanamina
| dc.contributor.advisor | Gómez Castaño, Jovanny Arlés | spa |
| dc.contributor.author | Corredor Montaña, Jeisson David | |
| dc.date.accessioned | 2019-03-29T16:17:56Z | |
| dc.date.available | 2019-03-29T16:17:56Z | |
| dc.date.issued | 2018 | |
| dc.description | 1 recurso en línea (100 páginas) : figuras, tablas. | spa |
| dc.description.abstract | Theoretical and experimental study of the reaction system and DA cycloaddition products of N-benzyl-1-(furan-2-yl)methanamine (1a), and N-benzyl-N-(furan-2-ylmethyl)acetamide (1b) was developed using maleic anhydride (AnM) as dienophile. Organic synthesis was carried out by adjusting the experimental methodologies within the framework of green chemistry. Spectroscopic characterization of all the molecules was completed through one and two-dimensional NMR, FTIR, FTRaman, Mass Spectrometry and computational vibrational calculations at the B3LYP/6-31G+(d) level. Cycloaddition adduct of amine 1a was obtained as a racemic mixture of exo isomer with monoclinic crystalline structure. The molecules are arranged forming central-symmetric dimers linked by hydrogen bonds. Preliminary computational study at the level B3LYP/6-31G+(d) of transition structures proposed for this system, allowed to identify some factors that can determine the mechanism of reaction. The two evaluated routes present factors can lead exo selectivity of the adduct. Experimental evidence of NMR and FTIR require complementary analyzes to give clarity regarding the intermediary detected. Amide 1b obtained by acetylation of amine 1a, was obtained as a mixture of E-Z isomers and conformers that presents differentiation of shields in NMR. Its cycloaddition produced the Z-exo isomer of the adduct, which presents cycloreversibility in solution at room temperature, regenerating the E-Z isomeric mixture. Also, the synthesis of the organic salts maleate and acetate of amine 1a was reported. | eng |
| dc.description.abstract | Se desarrolló el estudio teórico-experimental del sistema de reacción y los productos de cicloadición DA de N-bencil-1-(2-furanil)metanamina (1a), y N-bencil-N-(2-furanilmetilen)acetamida (1b); empleando como dienófilo anhídrido maléico (AnM). La síntesis se llevó a cabo modificando las metodologías experimentales en el marco de la química verde. La caracterización espectroscópica de todas las moléculas se realizó mediante espectroscopia de RMN mono y bidimensional, FTIR, FTRaman, Espectrometría de masas y cálculos computacionales vibracionales al nivel B3LYP/6-31G+(d). El aducto de cicloadición de la amina 1a se obtuvo como una mezcla racémica del isómero exo con estructura cristalina monoclínica. Las moléculas se acomodan formando dímeros centro-simétricos enlazados por puentes de hidrógeno. El estudio computacional preeliminar al nivel B3LYP/6-31G+(d) de estructuras de transición propuestas para éste sistema, permitió identificar algunos factores que pueden determinar el mecanismo de reacción. Las dos rutas evaluadas presentan factores que pueden conducir a la selectividad exo del aducto. Las evidencias experimentales de RMN y FTIR requieren análisis complementarios para dar claridad respecto al intermediario detectado. La amida 1b obtenida por acetilación de la amina 1a, se obtuvo como una mezcla de isómeros E-Z y confórmeros que presenta diferenciación de ambientes en RMN. Su cicloadición DA produjo el isómero Z-exo del aducto, que presenta cicloreversibilidad en solución a temperatura ambiente, regenerando la mezcla isomérica E-Z. También, se reportó la síntesis de las sales orgánicas maleato y acetato de la amina 1a. | spa |
| dc.description.degreelevel | Maestría | spa |
| dc.description.degreename | Magíster en Química | spa |
| dc.description.notes | Bibliografía y webgrafía: páginas 93-99. | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.citation | Corredor Montaña, J. D. (2018). Estudio teórico-experimental de la síntesis y propiedades físico-químicas de derivados de N-bencil-1-(2-furanil) Metanamina. (Tesis de maestría). Universidad Pedagógica y Tecnológica de Colombia, Tunja. http://repositorio.uptc.edu.co/handle/001/2506 | spa |
| dc.identifier.uri | http://repositorio.uptc.edu.co/handle/001/2506 | |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad Pedagógica y Tecnológica de Colombia | spa |
| dc.publisher.faculty | Facultad de Ciencias, Escuela de Posgrados. Maestría en Química | spa |
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| dc.rights | Copyright (c) 2018 Universidad Pedagógica y Tecnológica de Colombia | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.coar | http://purl.org/coar/access_right/c_abf2 | spa |
| dc.rights.creativecommons | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | spa |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
| dc.subject.armarc | Reacción de Diels-Alder | |
| dc.subject.armarc | Síntesis orgánica | |
| dc.subject.armarc | Cicloadición | |
| dc.subject.armarc | Maestría en Química - Tesis y disertaciones académicas | |
| dc.title | Estudio teórico-experimental de la síntesis y propiedades físico-químicas de derivados de N-bencil-1-(2-furanil) Metanamina | spa |
| dc.type | Trabajo de grado - Maestría | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_bdcc | spa |
| dc.type.coarversion | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/masterThesis | spa |
| dc.type.redcol | https://purl.org/redcol/resource_type/TM | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
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